Puiblications 2024

GLDADec: marker-gene guided LDA modeling for bulk gene expression deconvolution

Azuma I, Mizuno T, Kusuhara H.

Brief Bioinform. 2024 May 23;25(4):bbae315. doi: 10.1093/bib/bbae315.

Pubmed DOI

Investigation of normalization procedures for transcriptome profiles of compounds oriented toward practical study design

Mizuno T, Kusuhara H.

J Toxicol Sci. 2024;49(6):249-259. doi: 10.2131/jts.49.249.

Pubmed DOI

Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles

Wakasa K, Tamura R, Osaka S, Takei H, Asai A, Nittono H, Kusuhara H, Hayashi H.

Hepatol Commun. 2024 Mar 22;8(4):e0382. doi: 10.1097/HC9.0000000000000382.

Pubmed DOI

Difficulty in chirality recognition for Transformer architectures learning chemical structures from string representations.

Yoshikai Y, Mizuno T, Nemoto S, Kusuhara H.

Nat Commun. 2024 Feb 16;15(1):1197. doi: 10.1038/s41467-024-45102-8.

Pubmed DOI

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

Hanaoka K, Ikeno T, Iwaki S, Deguchi S, Takayama K, Mizuguchi H, Tao F, Kojima N, Ohno H, Sasaki E, Komatsu T, Ueno T, Maeda K, Kusuhara H, Urano Y.

Sci Adv. 2024 Feb 16;10(7):eadi8847. doi: 10.1126/sciadv.adi8847.

Pubmed DOI

Anti-Inflammatory Effects of a Novel Nuclear Factor- κ B Inhibitory Derivative Derived from Pyrazolo[3,4-d]Pyrimidine in Three Inflammation Models.

Baba H, Hosoya T, Ishida R, Tai K, Hatsuzawa S, Kondo Y, Kusuhara H, Kagechika H, Yasuda S.

J Pharmacol Exp Ther. 2024 Feb 15;388(3):788-797. doi: 10.1124/jpet.123.001904.

Pubmed DOI

Clinical symptoms, biochemistry, and liver histology during the native liver period of progressive familial intrahepatic cholestasis type 2.

Kondou H, Nakano S, Mizuno T, Bessho K, Hasegawa Y, Nakazawa A, Tanikawa K, Azuma Y, Okamoto T, Inui A, Imagawa K, Kasahara M, Zen Y, Suzuki M, Hayashi H.

Orphanet J Rare Dis. 2024 Feb 10;19(1):57. doi: 10.1186/s13023-024-03080-6.

Pubmed DOI

Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening.

Sakamoto S, Hiraide H, Minoda M, Iwakura N, Suzuki M, Ando J, Takahashi C, Takahashi I, Murai K, Kagami Y, Mizuno T, Koike T, Nara S, Morizane C, Hijioka S, Kashiro A, Honda K, Watanabe R, Urano Y, Komatsu T.

Cell Rep Methods. 2024 Jan 22;4(1):100688. doi: 10.1016/j.crmeth.2023.100688.

Pubmed DOI

Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset. NAR Genom Bioinform.

Azuma I, Mizuno T, Morita K, Suzuki Y, Kusuhara H.

NAR Genom Bioinform. 2024 Jan 5;6(1):lqad111. doi: 10.1093/nargab/lqad111.

Pubmed DOI