Puiblications 2023

Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition.

Ukegawa T, Komatsu T, Minoda M, Matsumoto T, Iwasaka T, Mizuno T, Tachibana R, Sakamoto S, Hanaoka K, Kusuhara H, Honda K, Watanabe R, Urano Y.

Adv Sci (Weinh). 2023 Dec 22:e2306559. doi: 10.1002/advs.202306559.

Pubmed DOI

Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, Tatsuya Okamoto, Seiichi Shimizu, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Satoru Takahashi, Hiroyuki Kusuhara, Yoh Zen, Tomohiro Ando & Hisamitsu Hayashi

Nat Commun. 2023 Nov 21;14(1):6763. doi: 10.1038/s41467-023-42424-x.

Pubmed DOI

Investigation of latent representation of toxicopathological images extracted by CNN model for understanding compound properties in vivo

Shotaro Maedera, Tadahaya Mizuno, Hiroyuki Kusuhara

Comput Biol Med. 2023 Nov 23:168:107748. doi: 10.1016/j.compbiomed.2023.107748.

Pubmed DOI

Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics Databases

Katsuhisa Morita, Tadahaya Mizuno, Iori Azuma, Yutaka Suzuki, Hiroyuki Kusuhara

Toxicol Sci. 2023 Nov 6:kfad117. doi: 10.1093/toxsci/kfad117.

Pubmed DOI

Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys

Yoshiki Hashimoto, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Akiko Moriyama, Tatsuya Oda, Hiroyuki Kusuhara

Toxicol In Vitro. 2023 Sep 1:93:105691. doi: 10.1016/j.tiv.2023.105691.

Pubmed DOI

Progress in the Quantitative Assessment of Transporter-Mediated Drug–Drug Interactions Using Endogenous Substrates in Clinical Studies.

Tatsuki Mochizuki, Hiroyuki Kusuhara

Drug Metab Dispos. 2023 Sep;51(9):1105-1113. doi: 10.1124/dmd.123.001285.

Pubmed DOI

Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism.

Sato H, Marutani R, Takaoka R, Mori-Fegan D, Wang X, Maeda K, Kusuhara H, Suzuki H, Yoshioka H, Hisaka A

CPT Pharmacometrics Syst Pharmacol. 2023 Aug;12(8):1132-1142. doi: 10.1002/psp4.12980.

Pubmed DOI

Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain.

Sho Sato, Siyu Liu, Akihiko Goto, Tomoki Yoneyama, Koki Okita, Syunsuke Yamamoto, Hideki Hirabayashi, Shinji Iwasaki, Hiroyuki Kusuhara

J Control Release. 2023 May:357:379-393. doi: 10.1016/j.jconrel.2023.04.012.

Pubmed DOI

Investigation of chemical structure recognition by encoder-decoder models in learning progress

Shumpei Nemoto, Tadahaya Mizuno, Hiroyuki Kusuhara

J Cheminform. 2023 Apr 12;15(1):45. doi: 10.1186/s13321-023-00713-z.

Pubmed DOI

The influence of serial 50 μL microsampling on rats administered azathioprine, the immunosuppressive drug

Yoichi Tanaka, Kazuaki Takahashi, Norimichi Hattori, Hideaki Yokoyama, Koki Yamaguchi, Yusuke Shibui, Sayaka Kawaguchi, Taishi Shimazaki, Keiko Nakai, Hiroyuki Kusuhara, Yoshiro Saito

Toxicol Rep. 2023 Mar 1;10:334-340. doi: 10.1016/j.toxrep.2023.02.016. PMID: 36923445

Pubmed DOI

Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method

Hiromu Ishiguro, Tadahaya Mizuno, Yasuo Uchida, Risa Sato, Hayate Sasaki, Shumpei Nemoto, Tetsuya Terasaki, Hiroyuki Kusuhara

NAR Genom Bioinform. 2023 Mar 11;5(1):lqad022. doi: 10.1093/nargab/lqad022. PMID: 36915410

Pubmed DOI

[Understanding of Multiple Effects of Low Molecular Weight Compounds with Factor Analysis]

Tadahaya Mizuno,Shumpei Nemoto, Katsuhisa Morita, Hiroyuki Kusuhara

Yakugaku Zasshi. 2023;143(2):127-132. doi: 10.1248/yakushi.22-00156-2. PMID: 36724926

Pubmed DOI

NRBdMF: A Recommendation Algorithm for Predicting Drug Effects Considering Directionality

Iori Azuma, Tadahaya Mizuno, Hiroyuki Kusuhara

J Chem Inf Model. 2023 Jan 12. doi: 10.1021/acs.jcim.2c01210. Online ahead of print. PMID: 36635231

Pubmed DOI

Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice

Akihiko Goto, Syunsuke Yamamoto, Tomoko Igari, Shin-Ichi Matsumoto, Ikumi Chisaki, Koichi Iida, Miyu Nakayama, Akira Oda, Yuuichi Kakoi, Akio Uchida, Kenichi Miyata, Makiya Nishikawa, Tetsuya Nagata, Hiroyuki Kusuhara, Takanori Yokota, Hideki Hirabayashi

J Pharmacol Exp Ther. 2023 Ja;384(1):197-204. doi: 10.1124/jpet.122.001331. PMID: 36273821

Pubmed DOI