分子薬物動態学教室

分子薬物動態学教室

Puiblications 2022

[Development of Decomposition Approach for Comprehensive Understanding of Drug Effects]

Tadahaya Mizuno

Yakugaku Zasshi. 2022;142(10):1077-1082. doi: 10.1248/yakushi.22-00123. PMID: 36184442

Pubmed DOI

A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes

Hideto Moriyama, Genki Ogata, Haruma Nashimoto, Seishiro Sawamura, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga

Analyst. 2022 Oct 10;147(20):4442-4449. doi: 10.1039/d2an01037b. PMID: 36129310

Pubmed DOI

Investigation of a Data Split Strategy Involving the Time Axis in Adverse Event Prediction Using Machine Learning

Katsuhisa Morita, Tadahaya Mizuno, Hiroyuki Kusuhara

J Chem Inf Model. 2022 Sep 12;62(17):3982-3992. doi: 10.1021/acs.jcim.2c00765. Epub 2022 Aug 16.PMID: 35971760

Pubmed DOI

Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies

Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, A David Rodrigues, Koji Chiba, Hiroyuki Kusuhara, Yuichi Sugiyama

CPT Pharmacometrics Syst Phramacol. 2022 Oct;11(10):1341-1357. doi: 10.1002/psp4.12849. Epub 2022 Aug 9.PMID: 35945914

Pubmed DOI

Frequency of null genotypes of glutathione S-transferase M1 and T1 in Japanese patients with drug-induced liver injury

Kazuya Maeda, Hajime Takikawa, Mitsuhiko Aiso, Kenji Tsuji, Tatehiro Kagawa, Masaaki Watanabe, Ken Sato, Shotaro Sakisaka, Yoichi Hiasa, Yoshiyuki Takei, Hiromasa Ohira, Etsuko Hashimoto, Minoru Ayada, Tadashi Ikegami, Noriaki Arakawa, Hiroyuki Kusuhara, Yoshiro Saito, Yuichi Sugiyama

Hepatol Res. 2022 Oct;52(10):882-887. doi: 10.1111/hepr.13812. Epub 2022 Aug 5.PMID: 35834381

Pubmed DOI

Clinical and genetic features of congenital bile acid synthesis defect with a novel mutation in AKR1D1 gene sequencing: Case reports

Anh-Hoa Nguyen Pham, Kim-Oanh Bui Thi, Mai-Huong Nguyen Thi, Diem-Ngoc Ngo, Nakayuki Naritaka, Hiroshi Nittono, Hisamitsu Hayashi, Trang Thi Dao, Kim-Huong Thi Nguyen, Hoai-Nghia Nguyen, Hoa Giang, Hung-Sang Tang, Tat-Thanh Nguyen, Dinh-Kiet Truong, Minh-Dien Tran

Medicine(Baltimore). 2022 Jun 24;101(25):e29476. doi: 10.1097/MD.0000000000029746. PMID: 35758383

Pubmed DOI

Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs

Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J Zamek-Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

Transl Sci. 2022 Jun;15(6):1519-1531. doi: 10.1111/cts.13272. Epub 2022 May 2.PMID: 35421902

Pubmed DOI

[

Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity

Takayoshi Nakaoka, Ken-Ichi Kaneko, Satsuki Irie, Aya Mawatari, Ami Igesaka, Yuta Uetake, Hidenori Ochiai, Takashi Niwa, Emi Yamano, Yasuhiro Wada, Masaaki Tanaka, Kohei Kotani, Hideki Kawahata, Joji Kawabe, Yukio Miki, Hisashi Doi, Takamitsu Hosoya, Maeda Kazuya, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasuyoshi Watanabe

Drug Metab Pharmacokinet. 2022 Jun;44:100449. doi: 10.1016/j.dmpk.2022.100449. Epub 2022 Feb 1. PMID: 35395593

Pubmed DOI

Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions

Tatsuki Mochizuki, Maciej J Zamek-Gliszczynski, Kenta Yoshida, Jialin Mao, Kunal Taskar, Hideki Hirabayashi, Xiaoyan Chu, Yurong Lai, Tadayuki Takashima, Kevin Rockich, Yoshiyuki Yamaura, Kaku Fujiwara, Tadahaya Mizuno, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

Clin Pharmacol Ther. 2022 Jun;111(6):1315-1323. doi: 10.1002/cpt.2584. Epub 2022 Apr 11.PMID: 35292967

Pubmed DOI

Usefulness of Human Jejunal Spheroid-Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans

Kazuyoshi Michiba, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Tatsuya Oda, Hiroyuki Kusuhara

Drug Metab Dispos. 2022 Mar;50(3):204-213. doi: 10.1124/dmd.121.000796. Epub 2022 Jan 6.PMID: 34992074

Pubmed DOI

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N Mayhew, Jennifer Hellmann, Alexander Miethke, Nahrin L Tasnova, Samuel J I Blackford, Zu Ming Tang, Adam M Syanda, Liang Ma, Fang Xiao, Melissa Sambrotta, Oliver Tavabie, Filipa Soares, Oliver Baker, Davide Danovi, Hisamitsu Hayashi, Richard J Thompson, S Tamir Rashid, Akihiro Asai

JHEP Rep. 2022 Feb 1;4(4):100446. doi: 10.1016/j.jhepr.2022.100446. eCollection 2022 Apr. PMID: 35284821

Pubmed DOI

Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood-brain barrier

Yoshiki Hashimoto, Kazuyoshi Michiba, Kazuya Maeda, Hiroyuki Kusuhara

J Pharmacol Sci. 2022 Jan;148(1):142-151. doi: 10.1016/j.jphs.2021.10.010. Epub 2021 Nov 2.PMID: 34924119

Pubmed DOI

<< 前のページに戻る