Puiblications 2021

Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders

Nakajima Y, Osaka S, Mizuno T, Yokoi K, Nakano S, Hirai S, Hiraoka Y, Miura Y, Suzuki M, Kusuhara H, Hayashi H.

Mol Genet Metab Rep. 2021 Sep 4;29:100799. doi: 10.1016/j.ymgmr.2021.100799. eCollection 2021 Dec. PMID: 34522617

Pubmed DOI

Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes

Deguchi S, Tsuda M, Kosugi K, Sakamoto A, Mimura N, Negoro R, Sano E, Nobe T, Maeda K, Kusuhara H, Mizuguchi H, Yamashita F, Torisawa YS, Takayama K.

ACS Biomater Sci Eng. 2021 Aug 9;7(8):3648-3657. doi: 10.1021/acsbiomaterials.1c00642. Epub 2021 Jul 20. PMID: 34283567

Pubmed DOI

Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure

Tsuboya A, Kubota Y, Ishida H, Ohkuma R, Ishiguro T, Hirasawa Y, Ariizumi H, Tsunoda T, Sasaki Y, Matsumoto N, Kondo Y, Tomoda Y, Kusuhara H, Fujita KI.

Cancer Chemother Pharmacol. 2021 Sep;88(3):543-553. doi: 10.1007/s00280-021-04314-1. Epub 2021 Jun 11. PMID: 34117512

Pubmed DOI

Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived From Human Induced Pluripotent Stem Cells

Kurosawa T, Tega Y, Sako D, Mochizuki T, Yamaguchi T, Kawabata K, Inoue K, Ito N, Kusuhara H, Deguchi Y.

J Pharm Sci. 2021 Oct;110(10):3484-3490. doi: 10.1016/j.xphs.2021.06.007. Epub 2021 Jun 5. PMID: 34102205

Pubmed DOI

Decomposition Profile Data Analysis for Deep Understanding of Multiple Effects of Natural Products

Shumpei Nemoto, Katsuhisa Morita, Tadahaya Mizuno, Hiroyuki Kusuhara

J Nat Prod. 2021 Apr 23;84(4):1283-1293. doi: 10.1021/acs.jnatprod.0c01381. Epub 2021 Apr 9. Epub 2020 Sep 22. PMID: 33836128

Pubmed DOI

A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers

Shuhei Osaka, Satoshi Nakano, Tadahaya Mizuno, Yuka Hiraoka, Kei Minowa, Saeko Hirai, Ayumu Mizutani, Yusuke Sabu, Yoshiki Miura, Toshiaki Shimizu, Hiroyuki Kusuhara, Mitsuyoshi Suzuki, Hisamitsu Hayashi

Mol Genet Metab. 2021 Apr;132(4):220-226. doi: 10.1016/j.ymgme.2021.02.002. Epub 2021 Feb 23. PMID: 33648834

Pubmed DOI

Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development.

Mochizuki T, Mizuno T, Maeda K, Kusuhara H.

Metab Pharmacokinet. 2021 Apr;37:100358. doi: 10.1016/j.dmpk.2020.09.003. Epub 2020 Sep 22. PMID: 33461054

Pubmed DOI

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation

Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A.

Stem Cell Reports. 2021 Feb 9;16(2):309-323. doi: 10.1016/j.stemcr.2020.12.008. Epub 2021 Jan 14. PMID: 33450190

Pubmed DOI

Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum.

Michiba K, Maeda K, Kurimori K, Enomoto T, Shimomura O, Takeuchi T, Nishiyama H, Oda T, Kusuhara H.

Drug Metab Dispos. 2021 Jan;49(1):84-93. doi: 10.1124/dmd.120.000138. Epub 2020 Oct 21. PMID: 33087448

Pubmed DOI

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes.

Yoshikado T, Lee W, Toshimoto K, Morita K, Kiriake A, Chu X, Lee N, Kimoto E, Varma MVS, Kikuchi R, Scialis RJ, Shen H, Ishiguro N, Lotz R, Li AP, Maeda K, Kusuhara H, Sugiyama Y.

J Pharm Sci. 2021 Jan;110(1):376-387. doi: 10.1016/j.xphs.2020.10.041. Epub 2020 Oct 27. PMID: 33122051

Pubmed DOI